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Lateralised alterations in forebrain monoaminergic systems and behavioural correlations in ADHD-like hyperactive and impulsive male rats
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DOI：10.1016/j.nbd.2026.107573.png)
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Abstract
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• ADHD-like hyperactivity-impulsivity involves all 3 forebrain monoaminergic systems. • Changes in forebrain monoaminergic systems markedly correlate with ADHD-like behavior. • The correlation is observed after delayed reward, a behavioral hallmark of human ADHD. • Affected regions: right and left prefrontal cortex, right posterior caudate-putamen. • The effect in each lateralized region involves a different monoaminergic system.
Keywords:
Dopaminergic system
Noradrenergic system
Serotonergic system
Extreme prematurity
Intermittent hypoxia
D-amphetamine
Predictive validity
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