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Left Atrioventricular Coupling Index in Health and Disease: A Longitudinal Multicohort Analysis
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DOI：10.1016/j.jocmr.2026.102761.png)
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Abstract
En 中文
The Left Atrioventricular Coupling Index (LACI), calculated as the ratio of left atrial (LA) to left ventricular (LV) end-diastolic volume (EDV) has emerged as a novel imaging biomarker of LA-LV coupling. However, reference thresholds are undefined and its predictive value beyond established clinical and imaging markers remains uncertain, limiting broader clinical implementation.
Keywords:
AF
atrial fibrillation
CI
confidence interval
CMR
cardiovascular magnetic resonance
CVD
cardiovascular disease
EDV
end-diastolic volume
EF
ejection fraction
GCS
global circumferential strain
GLS
global longitudinal strain
GRS
global radial strain
HES
Hospital Episode Statistics
HF
heart failure
HHC
Healthy Hearts Consortium
ICD
International Classification of Disease
LA
left atrium
LACI
left atrioventricular coupling index
LAS
long axis shortening
LV
left ventricle
LVFP
left ventricular filling pressure
LVM
left ventricular mass
MAPSE
mitral annular plane systolic excursion
MI
myocardial infarction
PI
prediction interval
QC
quality control
SD
standard deviation
SHIP
Study of Health in Pomerania
cardiac magnetic resonance
left atrioventricular coupling index
atrial fibrillation
heart failure
normal reference ranges
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