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Legionnaires disease
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DOI：10.1016/j.lpm.2006.10.012.png)
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Legionnaires disease, more formally known as legionellosis, is a relatively common form of severe pneumonia caused by Legionella, a genus of waterborne bacteria. Legionellosis is acquired by inhalation of legionellae from contaminated environmental sources. Legionella pneumophila serogroup 1 is responsible for more than 80% of cases in most countries. More than 1500 cases were reported in France in 2005. Initial diagnosis is based on tests for urinary antigens. The mortality rate for legionellosis depends on the promptness of appropriate antibiotic therapy. Macrolides (erythromycin or intravenous azithromycin, which is preferred to erythromycin for its better pharmucodynamic properties) and fluoroquinolones (levofloxocin) ore the antibiatics of choice for severe legionellosis.
Keyword:
COMMUNITY-ACQUIRED PNEUMONIA
LEGIONELLA-PNEUMOPHILA
EFFICACY
THERAPY
SUSCEPTIBILITY
TELITHROMYCIN
LEVOFLOXACIN
MACROPHAGES
RECEPTOR-4
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