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Leishmaniasis

delete2025-11-20
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PRE
AI
M
Myrthe Pareyn
F
Fabiana Alves
S
Sakib Burza
J
Jaya Chakravarty
J
Jorge Alvar
E
Ermias Diro
P
Paul M. Kaye
J
Johan van Griensven *
DOI:10.1038/s41572-025-00663-wdelete
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摘要

摘要

En 中文
利什曼病是亚洲、非洲、美洲和南欧的一种地方性流行病,由利什曼原虫引起,通过雌性沙蝇叮咬传播,导致巨噬细胞内利什曼原虫复制。该病表现为内脏利什曼病(一种可能致命的全身性疾病,导致持续性发热、肝脾肿大[肝脾肿大]以及几乎所有血细胞减少[全血细胞减少])或皮肤利什曼病(以溃疡性或非溃疡性皮肤损伤为特征)。疾病表现和严重程度由病原体、宿主和媒介特征决定,并涉及复杂的免疫相互作用。rK39快速诊断试验是诊断内脏利什曼病的主要方法,而皮肤利什曼病通常通过皮肤样本显微镜检查进行诊断。内脏利什曼病和严重形式的皮肤利什曼病通过系统性治疗管理。对于局限性皮肤利什曼病,治疗包括局部疗法,如冷冻疗法、热疗和/或使用抗锑剂进行皮损内注射。世界卫生组织2021-2030年忽视热带病路线图旨在消除内脏利什曼病作为公共卫生问题,并加强皮肤利什曼病的控制。在南亚,一个区域性内脏利什曼病项目显著减少了病例负担。东非最近启动了类似的倡议。利什曼病的控制和消除取得可持续进展需要更好的诊断、治疗和媒介控制干预措施,以及疫苗开发的进展、政治承诺、改进的监测和卫生服务。利什曼病是由利什曼原虫引起并通过雌性沙蝇叮咬传播的地方性流行病。在本综述中,Pareyn及其同事回顾了利什曼病的流行病学和病理生理学,讨论了当前的诊断和管理,并确定了未来的研究方向。
Keyword:
Leishmaniasis
visceral leishmaniasis
cutaneous leishmaniasis
diagnostic test
treatment

期刊

N
Nature Reviews Disease Primers
IF:
60.6
论文数:
648
被引数:
3.8W

机构

U
University of Washington
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被引数: 12.5W
U
University of York
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1.3K
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London School of Hygiene and Tropical Medicine
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1.8K
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I
Institute of Tropical Medicine
学者数:
331
论文数: 122
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R
royal academy of medicine
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1
论文数: 1
被引数: 0
B
Banaras Hindu University
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849
论文数: 367
被引数: 1.2W
D
Drugs for Neglected Diseases Initiative
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13
论文数: 3
被引数: 337
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引用论文

引用论文

Natural Resistance of Leishmania infantum to Miltefosine Contributes to the Low Efficacy in the Treatment of Visceral Leishmaniasis in Brazil婴儿利什曼原虫对米替福新的自然抗性导致巴西内脏利什曼病的疗效低下
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errJuliana B. T. Carnielli; Renata Monti-Rocha; Dorcas Lamounier Costa; Aretha Molina Sesana; Laura N. N. Pansini; Marcela Segatto; Jeremy C. Mottram; Carlos Henrique Nery Costa; Sílvio F. G. Carvalho; Reynaldo Dietze
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Prognostic prediction models for clinical outcomes in patients diagnosed with visceral leishmaniasis: protocol for a systematic review诊断为内脏利什曼病患者的临床预后预测模型: 系统评价方案
err2023-10-24
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errJames Wilson; Forhad Chowdhury; Shermarke Hassan; Elinor K Harriss; Fabiana Alves; Prabin Dahal; Kasia Stepniewska; Philippe J Guérin
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A critical review of the applicability of serological screening for Leishmaniasis in blood banks in Brazil对巴西血库中利什曼病血清学筛查的适用性的严格审查
err2020-10-08
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errWellington Francisco Rodrigues; Niege Silva Mendes; Patrícia de Carvalho Ribeiro; Daniel Mendes Filho; Ricardo Cambraia Parreira; Karen Cristina Barbosa Chaves; Melissa Carvalho Martins de Abreu; Camila Botelho Miguel
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Genome diversity of Leishmania aethiopica埃塞俄比亚利什曼原虫的基因组多样性
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errAmber Hadermann; Senne Heeren; Ilse Maes; Jean-Claude Dujardin; Malgorzata Anna Domagalska; Frederik Van den Broeck
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Gut Microbiota and Lymphocyte Subsets in Canine Leishmaniasis肠道微生物群和淋巴细胞亚群在犬利什曼病中的作用
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errSara Meazzi; Stefania Lauzi; Valeria Martini; Riccardo Ferriani; Margherita Peri; Sergio Aurelio Zanzani; Alessia Giordano
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Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral LeishmaniasisI型干扰素可抑制抗寄生虫免疫,并可靶向改善内脏利什曼病的治疗
err2020-02-01
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errKumar, Rajiv; Bunn, Patrick T.; Singh, Siddharth Sankar; Ng, Susanna S.; de Oca, Marcela Montes; Rivera, Fabian De labastida; Chauhan, Shashi Bhushan; Singh, Neetu; Faleiro, Rebecca J.; Edwards, Chelsea L.; Frame, Teija C. M.; Sheel, Meru; Austin, Rebecca J.; Lane, Steven W.; Bald, Tobias; Smyth, Mark J.; Hill, Geoffrey. R.; Best, Shannon E.; Haque, Ashraful; Corvino, Dillon; Waddell, Nic; Koufariotis, Lambross; Mukhopadhay, Pamela; Rai, Madhukar; Chakravarty, Jaya; Singh, Om Prakash; Sacks, David; Nylen, Susanne; Uzonna, Jude; Sundar, Shyam; Engwerda, Christian R.
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