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Line-scan focal modulation microscopy
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DOI：10.1117/1.JBO.22.5.050502.png)
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We report the development of a line-scan focal modulation microscope (LSFMM) that is capable of highspeed image acquisition (>40 fps) with uncompromised optical sectioning capability. The improved background rejection and axial resolution of this imaging modality, enabled by focal modulation, are quantified with three-dimensional imaging data obtained from fluorescent beads. The signal-to-background ratio for the LSFMM system is one-to two-orders of magnitude higher than that for line-scanning confocal systems when imaging deep (up to 100 mu m) into a turbid medium of optical properties similar to biological tissues. The imaging performance of LSFMM, in terms of both spatial and temporal resolutions, is further demonstrated with in vivo imaging experiments with live zebrafish larvae. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Keyword:
fluorescence microscopy
confocal
line-scan
focal modulation
speed
background rejection
期刊
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2.9
论文数:
7.4K
被引数:
1.4W
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