Linking data to models: data regression

Khuloud Jaqaman

doi:10.1038/nrm2030

2006-09-27

195

PRE

Khuloud Jaqaman

Gaudenz Danuser *

DOI：10.1038/nrm2030

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摘要

En 中文

Mathematical models are an essential tool in systems biology, linking the behaviour of a system to the interactions between its components. Parameters in empirical mathematical models must be determined using experimental data, a process called regression. Because experimental data are noisy and incomplete, diagnostics that test the structural identifiability and validity of models and the significance and determinability of their parameters are needed to ensure that the proposed models are supported by the available data.

Keyword:

KINETOCHORE MICROTUBULE DYNAMICS

BIOCHEMICAL PATHWAYS

PARAMETER-ESTIMATION

SINGLE-CELL

SQUARES REGRESSION

BAYESIAN-ANALYSIS

INDUCED APOPTOSIS

TIME-SERIES

YEAST

NETWORKS

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期刊

Nature Reviews Molecular Cell Biology

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90.2

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