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LIPUS combined with mild hyperthermia promotes rotator cuff healing via TRPV1/Ca2+/CaMKII-driven BACH2 nuclear translocation and inhibition of M1 polarization
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DOI：10.1016/j.jot.2026.101170.png)
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Abstract
En 中文
Rotator cuff injuries often lead to impaired shoulder function, and tendon–bone healing remains challenging due to the complex structure of the enthesis and persistent remodeling-associated pro-inflammatory signaling. Low-intensity pulsed ultrasound (LIPUS) and mild hyperthermia (MH) have shown potential in tissue repair, but the molecular mechanisms underlying their combined effects are unclear.
Keywords:
Rotator cuff injury
Tendon–bone healing
LIPUS
Mild hyperthermia
Macrophages
TRPV1/Ca2+/CaMKII/BACH2
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7.8
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1.1K
Citations:
4.1K
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