.png){kind=icon}
返回
LNCing RNA to immunity
.png){kind=icon}
OA
AI
DOI：10.1016/j.it.2022.04.002.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Despite an ever-increasing appreciation of how protein-coding genes shape immune responses, the molecular underpinnings of immune regulation remain incompletely understood. This incomplete picture impedes the development of more precise therapeutics and diagnostics for immune-mediated diseases. Long noncoding RNAs (lncRNAs) are versatile cell- and context-specific regulators of gene expression and cellular function. The number of lncRNA genes rivals that of protein-coding genes; however, comparatively little is known about their function. Even though the functions of most lncRNA genes are unknown, multiple lncRNAs have recently emerged as important immune regulators. Therefore, further unlocking the role of lncRNAs in the mammalian immune system coupled with their tissue-specific expression might lead to more precise therapeutics and diagnostics for immune disorders in general.
Keyword:
LONG-NONCODING RNA
HEMATOPOIETIC STEM
PROGENITOR CELLS
B-CELL
LNCRNA
EXPRESSION
CANCER
DIFFERENTIATION
TRANSCRIPTION
PROMOTES
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
13.9
论文数:
2.7K
被引数:
1.7W
机构
引用论文
Expression of novel long noncoding RNAs defines virus-specific effector and memory CD8+ T cells.png)
NATURE COMMUNICATIONSOAAI
NATURE COMMUNICATIONSIF15.7
OAAI分享收藏The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasionNATURE COMMUNICATIONSOAAI
NATURE COMMUNICATIONSIF15.7
OAAI分享收藏Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineagesNATURE IMMUNOLOGYOAAI
NATURE IMMUNOLOGYIF27.6
OAAI分享收藏The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune responseNATURE IMMUNOLOGY
NATURE IMMUNOLOGYIF27.6
PREAI
分享收藏
查看更多内容