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Loss of Snord115 mitigates Snord116-driven sleep abnormalities in mouse models of Prader-Willi syndrome

delete2026-07-30
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J
Julie C. Rivière *
V
Virginie Marty
J
Jérôme Cavaillé *
L
Laure Verret *
DOI：10.1016/j.nbd.2026.107551delete
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Abstract

Abstract

En 中文
• Snord116 deletion disrupts sleep architecture in mice. • Snord115 loss suppresses Snord116-dependent REM sleep abnormalities. • REM sleep changes occur independently of MCH neuron decrease. • Hypothalamic transcriptomic changes are limited across genotypes.
Keywords:
snoRNA
SNORD116
SNORD115
Prader-Willi syndrome
REM sleep
Hypocretin
MCH

Journal

Neurobiology of Disease cover
Neurobiology of Disease
IF:
5.6
Papers:
6.7K
Citations:
2.1W

Organization

C
centre de biologie integrativ
Scholars:
3
Papers: 1
Citations: 0
C
cnrs
Scholars:
2.9K
Papers: 1.3K
Citations: 88
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