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Low microRNA-338-3p expression drives cutaneous squamous cell carcinoma progression and predicts poor prognosis
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DOI：10.1515/tjb-2025-0173.png)
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Abstract
En 中文
Objectives To explore the clinical significance and influence of miR-338-3p in cSCC.Methods The content of miR-338-3p in cSCC was quantified using qRT-PCR. Prognostic relevance of miR-338-3p in cSCC was evaluated via Kaplan-Meier curve analysis. Functional roles of miR-338-3p in cSCC cell behavior were assessed through MTT assays, transwell assays.Results miR-338-3p was low-expressed in cSCC, with levels linked with lymph node metastasis, TNM stage, and disease progression. Statistically, miR-338-3p was a predictor of poor prognosis in cSCC. Functionally, miR-338-3p restoration weakened cSCC cellular viability and metastatic potential in vitro.Conclusions In cSCC, miR-338-3p exhibited downregulated expression, which suppressed cell viability, migratory behaviors, and invasive abilities. It has potential as a predictor for prognosis and a therapeutic target in cSCC.
Keywords:
cSCC
miR-338-3p
prognosis
proliferation
migration
invasion
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