Lower expression of BRCA1 in cardiomyoblast alters the expression of apoptotic, inflammatory and metabolic pathway genes, and enhances catecholamine-induced hypertrophic response

2026-06-02

PRE

Ubaid Tariqa

Soumalya Sarkar

Roshan Kumara

Samhita Chakraborty

Paramesha Bugga

Praloy Chakraborty

Sanjay K Banerjeea *

DOI：10.1016/j.gene.2026.150249

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• BRCA1 regulates apoptosis, inflammation, metabolism and hypertrophy-related gene expression in cardiomyoblasts. • Lentiviral knockdown of BRCA1 increases cardiomyoblast susceptibility to hypertrophy, fibrosis, and remodeling upon isoproterenol exposure.

Lower expression of BRCA1 in cardiomyoblast alters the expression of apoptotic, inflammatory and metabolic pathway genes, and enhances catecholamine-induced hypertrophic response

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