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Lung metastases

delete2025-08-21
delete0
PRE
AI
L
Lodovica Zullo
D
Dimitris Filippiadis
L
Lizza Hendriks
D
Daniel Portik
J
Jonathan Spicer
I
Ignacio I. Wistuba
B
Benjamin Besse *
DOI：10.1038/s41572-025-00642-1delete
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摘要

摘要

En 中文
高达50%的转移性癌症患者在其疾病过程中会出现肺转移。肺转移与多种癌症类型的预后不良相关，并可能损害患者的生活质量，导致呼吸困难、咳嗽、咯血和疼痛，从而可能降低患者的身体、功能及情感健康水平。肺转移源于肿瘤分泌因子（如VEGF、TGFβ和CCL2）的复杂相互作用，这些因子驱动血管重塑、免疫细胞募集和细胞外基质重编程。此外，肿瘤来源的细胞外囊泡和微粒通过改变肺微环境，促进器官特异性转移和免疫抑制。这些修饰共同形成一个有利于肿瘤细胞定植和生长的转移前微环境。肺转移主要通过影像学诊断；有时需要组织学确认以将其与原发性肺癌区分。肺转移的大小和数量、原发癌治疗时机、组织学特征以及患者的临床状况均需考虑，以确定最合适的治疗方案。当局部区域治疗不可行时，基于组织学、分子驱动的全身治疗是首选方案。目前尚无专门针对肺转移的全身治疗方案。对转移前微环境形成和肺转移生长不同阶段的理解进展，可能有助于预防策略和个体化治疗的发展。肺是多种癌症的常见转移部位，包括结直肠癌、原发性肺癌、乳腺癌和前列腺癌。本综述概述了肺转移的流行病学、机制和诊断，讨论了各种治疗选择及其对生活质量的影响，并强调了当前和未来的研究方向。

期刊

N
Nature Reviews Disease Primers
IF:
60.6
论文数:
650
被引数:
3.8W

机构

C
cancer medicine department
学者数:
4
论文数: 2
被引数: 0
D
Department of Translational Molecular Pathology
学者数:
36
论文数: 10
被引数: 0
U
university general hospital “attikon” medical school
学者数:
2
论文数: 2
被引数: 0
F
Faculty of Medicine and Health Sciences
学者数:
544
论文数: 253
被引数: 0
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