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Müller Glial Cell-Dependent Regeneration of the Retina in Zebrafish and Mice
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DOI：10.1146/annurev-genet-111523-102000.png)
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Abstract
En 中文
Sight is one of our most precious senses. People fear losing their sight more than any other disability. Thus, restoring sight to the blind is an important goal of vision scientists. Proregenerative species, such as zebrafish, provide a system for studying endogenous mechanisms underlying retina regeneration. Nonregenerative species, such as mice, provide a system for testing strategies for stimulating retina regeneration. Key to retina regeneration in zebrafish and mice is the M & uuml;ller glial cell, a malleable cell type that is amenable to a variety of regenerative strategies. Here, we review cellular and molecular mechanisms used by zebrafish to regenerate a retina, as well as the application of these mechanisms, and other strategies to stimulate retina regeneration in mice. Although our focus is on M & uuml;ller glia (MG), niche components and their impact on MG reprogramming are also discussed.
Keywords:
regeneration
M & uuml
ller glia
immune
stem cell
reprogramming
dedifferentiation
Notch
ribosome
microglia
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