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Macronutrient availability and immune cell responses

delete2026-04-27
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PRE
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P
Paulo Estevão
A
Ana Julia Estumano Martins
P
Pedro M. Moraes-Vieira *
DOI:10.1016/j.smim.2026.102027delete
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摘要

摘要

En 中文
营养状况和膳食成分深刻影响免疫应答,其中碳水化合物、脂质和蛋白质作为免疫细胞代谢、活化和功能的关键调节因子。本综述综合了当前证据,阐述这些宏量营养素如何塑造固有免疫和适应性免疫细胞(包括单核细胞、巨噬细胞、树突状细胞、中性粒细胞、T细胞和B细胞)的行为。我们讨论了葡萄糖和果糖如何差异性地调控炎症通路、训练免疫和抗病毒反应;饱和与多不饱和脂肪酸如何影响免疫细胞信号传导和细胞因子产生;以及氨基酸可及性如何影响代谢重编程、极化和效应功能。新兴研究发现强调了宏量营养素在健康与疾病中的复杂、情境依赖性作用,揭示了它们在免疫介导性疾病中作为膳食靶点的潜力。理解这些相互作用为旨在调节代谢性、感染性和炎症性疾病免疫的营养策略奠定了基础。
Keyword:
Macronutrients
Immune cell metabolism
Dietary composition
Inflammatory pathways
Trained immunity

期刊

Seminars in Immunology 封面图
Seminars in Immunology
IF:
7.8
论文数:
1.6K
被引数:
7.3K

机构

U
University of Campinas
学者数:
958
论文数: 394
被引数: 1
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