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Making brain-machine interfaces robust to future neural variability

delete2016-12-13
delete134
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OA
AI
D
David Sussillo
S
Sergey D. Stavisky
J
Jonathan C. Kao
S
Stephen I. Ryu
K
Krishna V. Shenoy *
DOI:10.1038/ncomms13749delete
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摘要

摘要

En 中文
A major hurdle to clinical translation of brain-machine interfaces (BMIs) is that current decoders, which are trained from a small quantity of recent data, become ineffective when neural recording conditions subsequently change. We tested whether a decoder could be made more robust to future neural variability by training it to handle a variety of recording conditions sampled from months of previously collected data as well as synthetic training data perturbations. We developed a new multiplicative recurrent neural network BMI decoder that successfully learned a large variety of neural-to-kinematic mappings and became more robust with larger training data sets. Here we demonstrate that when tested with a non-human primate preclinical BMI model, this decoder is robust under conditions that disabled a state-of-the-art Kalman filter-based decoder. These results validate a new BMI strategy in which accumulated data history are effectively harnessed, and may facilitate reliable BMI use by reducing decoder retraining downtime.
Keyword:
LOCAL-FIELD POTENTIALS
MOTOR CORTEX
PREMOTOR
MOVEMENTS
DISCHARGE
FEEDBACK
PEOPLE
SPACE
TERM
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期刊

Nature Communications 封面图
Nature Communications
IF:
15.7
论文数:
9.4W
被引数:
91.2W

机构

S
Stanford University
学者数:
1.6K
论文数: 595
被引数: 0
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