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Malignant Gliomas: Simplifying the Complexity
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DOI：10.1158/2159-8290.CD-19-1081.png)
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The dramatic intertumoral and intratumoral heterogeneity in glioblastoma represents a formidable obstacle to finding effective combination targeted therapy for each individual patient. The article by Wang and colleagues in this issue of Cancer Discovery adds to a growing body of literature that points to these diverse aberrant genomes coalescing onto a very limited number of cellular states, reviving the hope of eventually identifying and therapeutically targeting just a few central gene-regulatory targets in most gliomas.
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分享收藏The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation.png)
CANCER DISCOVERY
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CANCER DISCOVERYIF33.3
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