Manipulating mitochondrial gene expression

Drishan Dahal

doi:10.1515/hsz-2025-0170

2025-09-01

Drishan Dahal

Luis D. Cruz-Zargoza

Peter Rehling *

DOI：10.1515/hsz-2025-0170

原文链接

原文求助

摘要

En 中文

线粒体对细胞代谢至关重要，是腺苷三磷酸（ATP）的主要来源。这种能量由位于线粒体内膜上的氧化磷酸化（OXPHOS）系统产生。该系统的功能障碍与严重的人类疾病相关，特别是在高能量需求组织中。OXPHOS系统的组装需要核基因组和线粒体基因组编码的基因协同表达。线粒体DNA编码13种蛋白质组分，这些组分由线粒体核糖体合成，并在翻译过程中插入到内膜中。尽管取得了进展，但线粒体基因表达调控的关键方面仍不明确，这主要归因于该细胞器的遗传可及性有限。然而，新兴技术现提供新工具来操纵该过程的各个阶段。在本综述中，我们探讨了近期扩展我们基因靶向线粒体能力的策略。

Keyword:

gene expression

genetic tools

mitochondria

RNA

期刊

Journal of Biological Chemistry

IF:

3.9

论文数:

11.2W

被引数:

28.3W

机构

暂无机构信息

引用论文

Microsecond Dynamics of Protein–DNA Interactions: Direct Observation of the Wrapping/Unwrapping Kinetics of Single-stranded DNA around the E.coli SSB Tetramer

Journal of Molecular Biology

IF0

2006-05-01

PREAI

Serguei V. Kuznetsov; Alexander G. Kozlov; Timothy M. Lohman; Anjum Ansari

Organization and Regulation of Mitochondrial Protein Synthesis 线粒体蛋白质合成的组织与调控

ANNUAL REVIEW OF BIOCHEMISTRY

IF0

2016-06-02

201

OAAI

Ott, Martin; Amunts, Alexey; Brown, Alan

Mitochondrial Lysyl-tRNA Synthetase Independent Import of tRNA Lysine into Yeast Mitochondria

PLoS ONE

IF0

2012-04-23

OAAI

Naresh Babu V. Sepuri; Madhavi Gorla; Michael P. King

A transcription factor required for promoter recognition by human mitochondrial RNA polymerase. Accurate initiation at the heavy- and light-strand promoters dissected and reconstituted in vitro.

Journal of Biological Chemistry

IF0

1985-09-01

OAAI

R P Fisher; D A Clayton

RNA processing in human mitochondria 人类线粒体中的RNA加工

CELL CYCLE

IF3.4

2014-10-28

223

OAAI

Sanchez, Maria I. G. Lopez; Mercer, Tim R.; Davies, Stefan M. K.; Shearwood, Anne-Marie J.; Nygard, Karoline K. A.; Richman, Tara R.; Mattick, John S.; Rackham, Oliver; Filipovska, Aleksandra

Silencing mitochondrial gene expression in living cells 在活细胞中沉默线粒体基因表达

Science

IF45.8

2025-05-22

PREAI

Luis Daniel Cruz-Zaragoza; Drishan Dahal; Mats Koschel; Angela Boshnakovska; Aiturgan Zheenbekova; Mehmet Yilmaz; Marcel Morgenstern; Jan-Niklas Dohrke; Julian Bender; Anusha Valpadashi; Kristine A. Henningfeld; Silke Oeljeklaus; Laura Sophie Kremer; Mirjam Breuer; Oliver Urbach; Sven Dennerlein; Michael Lidschreiber; Stefan Jakobs; Bettina Warscheid; Peter Rehling

Expression of green fluorescent protein from a recoded gene inserted into Saccharomyces cerevisiae mitochondrial DNA

Mitochondrion

IF4.5

2001-08-01

PREAI

Cohen, JS; Fox, TD

LRPPRC and SLIRP Interact in a Ribonucleoprotein Complex That Regulates Posttranscriptional Gene Expression in Mitochondria

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2010-04-15

243

OAAI

Sasarman, Florin; Brunel-Guitton, Catherine; Antonicka, Hana; Wai, Timothy; Shoubridge, Eric A.

POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA

SCIENCE ADVANCES

IF12.5

2016-08-05

102

OAAI

Kuehl, Inge; Miranda, Maria; Posse, Viktor; Milenkovic, Dusanka; Mourier, Arnaud; Siira, Stefan J.; Bonekamp, Nina A.; Neumann, Ulla; Filipovska, Aleksandra; Polosa, Paola Loguercio; Gustafsson, Claes M.; Larsson, Nils-Goran

Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress

PLOS ONE

IF0

2015-03-30

OAAI

Masataka Ikeda; Tomomi Ide; Takeo Fujino; Shinobu Arai; Keita Saku; Takamori Kakino; Henna Tyynismaa; Toshihide Yamasaki; Ken-ichi Yamada; Dongchon Kang; Anu Suomalainen; Kenji Sunagawa

查看更多内容