Mast Cell Activation Disorders

doi:10.1016/j.jaip.2014.03.007

2014-05-01

PRE

Cem Akin *

DOI：10.1016/j.jaip.2014.03.007

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摘要

En 中文

Disorders associated with mast cell activation range from relatively common IgE-mediated disease and chronic urticaria to rarer conditions such as mastocytosis or monoclonal mast cell activation disorder. Mast cell activation disorders can be mechanistically classified into primary (associated with abnormal production of mast cells that carry pathologic markers of clonality), secondary (normal mast cells activated in reaction to a microenvironmental trigger), and idiopathic (no etiology is found). Clinical presentations, diagnostic criteria as well as general principles of a stepwise therapy approach are discussed. (C) 2014 American Academy of Allergy, Asthma & Immunology

Keyword:

Mast cells

Mastocytosis

Mast cell activation syndromes

Diagnosis

Treatment

Tryptase c-kit

期刊

Journal of Allergy and Clinical Immunology in Practice

IF:

6.6

论文数:

5.3K

被引数:

1.6W

机构

Harvard University

学者数:

26.5W

论文数: 22.0W

被引数: 28.7W

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