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MCART1 (SLC25A51) deficiency exacerbates mitochondrial dysfunction during MPP+-induced complex I stress
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DOI：10.1016/j.freeradbiomed.2026.08.022.png)
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Abstract
En 中文
• MCART1 deficiency exacerbates mitochondrial dysfunction, manifested by loss of mitochondrial membrane potential, ATP depletion, and ROS accumulation. • MCART1-mediated mitochondrial NAD+ import is essential for sustaining mitochondrial function and cell survival under Parkinsonian stress. • Loss-of-function mutations in the key NAD+-binding sites abolish the protective activity of MCART1.
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