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MDM2 deletion and its associated p53 activation in subcutaneous white adipose tissue induce hepatic fibrosis via galectin-3 in a mouse model
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王
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C
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Y
李
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DOI：10.1016/j.metabol.2026.156726.png)
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Abstract
En 中文
• MDM2 deletion induces adipocyte senescence and death, and alters the secretome in sWAT. • MDM2 deletion and its associated p53 activation in sWAT drive hepatic damage, inflammation, and fibrosis. • p53 transcriptionally induces galectin-3 in adipocyte via binding to its promoter. • p53-galectin-3 activation in sWAT induces fibrogenesis in hepatic stellate cells.
Keywords:
ALT
alanine aminotransferase
AST
aspartate aminotransferase
MASLD
metabolic dysfunction-associated steatotic liver disease
H&E
hematoxylin and eosin
sWAT
subcutaneous white adipose tissue
vWAT
visceral white adipose tissue
eWAT
epididymal white adipose tissue
BAT
Brown adipose tissue
SASP
senescence-associated secretory phenotypes
AAV
adeno-associated virus
STC
standard chow
HFHC
high-fat high cholesterol
SVF
stromal vascular fraction
HSC
hepatic stellate cell
NPC
non-parenchymal cell
PCA
principal component analysis
DIA
data independent acquisition
IPA
ingenuity pathway analysis
CM
conditioned medium
White adipose tissue dysfunction
Liver fibrosis
Galectin-3
p53
Adipokine
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