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Mechanism, biomarkers, and therapeutic significance of trophoblastic ferroptosis in recurrent miscarriage
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DOI：10.1016/j.tice.2026.103543.png)
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Abstract
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• Trophoblastic ferroptosis, driven by iron overload and lipid peroxidation, plays a key role in recurrent miscarriage pathogenesis, impairing placental development and immune tolerance. • Biomarkers such as elevated ferritin/MDA and reduced GPX4, alongside omics signatures, enable early RM detection and risk stratification. • Therapeutic strategies including iron chelators (e.g., deferoxamine) and ferroptosis inhibitors (e.g., ferrostatin-1) show promise in preclinical models for improving pregnancy outcomes. • Future directions emphasize trophoblast-specific inhibitors, multi-omics integration, and personalized therapies based on maternal iron phenotypes to mitigate RM.
Keywords:
trophoblastic ferroptosis
recurrent miscarriage
iron overload
lipid peroxidation
biomarkers
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