Mechanistic insights into TNF-α and EGF-mediated vascular endothelial activation following PM2.5-induced alveolar injury

Tingting Wu

doi:10.1016/j.jhazmat.2026.143204

Mechanistic insights into TNF-α and EGF-mediated vascular endothelial activation following PM2.5-induced alveolar injury

2026-08-04

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AI

T

Tingting Wu

Z

Zhigang Li *

X

Xinping Yang

R

Rongrong Xu

Y

Yan Ding *

Y

Yongjie Wei *

DOI：10.1016/j.jhazmat.2026.143204

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• A novel 3D model has been developed to simulate the alveolar–vascular barrier in vitro. • PM2.5 exposure increased EGF and TNF-α expression in pulmonary epithelial cells. • EGF and TNF-α secreted by pulmonary epithelial cells transmit signals to vascular endothelial cells. • EGF and TNF-α regulate Nrf2 and CYP1A1expression in endothelial cells via the PI3K/Akt pathway. • Reveal the molecular link between alveolar injury and vascular endothelial dysfunction.

Mechanistic insights into TNF-α and EGF-mediated vascular endothelial activation following PM2.5-induced alveolar injury

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