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MeCP2 in the nucleus accumbens regulates operant cocaine self-administration and effort-based responding
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DOI：10.1016/j.pbb.2026.174167.png)
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Abstract
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• NAc MeCP2 knockdown increases operant cocaine self-administration at the unit dose tested. • shMeCP2 mice show higher cocaine infusions and active lever responding than controls during the maintenance phase and under a progressive-ratio schedule. • NAc MeCP2 knockdown does not alter baseline locomotion, anxiety-like behavior, or food-reinforced operant performance. • CPP-assessed cocaine-conditioned reward does not differ between groups under matched passive cocaine exposure (single dose).
Keywords:
MeCP2
nucleus accumbens
cocaine self-administration
operant behavior
effort-based responding
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