.png){kind=icon}
返回
MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods
.png){kind=icon}
OA
AI
DOI：10.1093/molbev/msr121.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Comparative analysis of molecular sequence data is essential for reconstructing the evolutionary histories of species and inferring the nature and extent of selective forces shaping the evolution of genes and species. Here, we announce the release of Molecular Evolutionary Genetics Analysis version 5 (MEGA5), which is a user-friendly software for mining online databases, building sequence alignments and phylogenetic trees, and using methods of evolutionary bioinformatics in basic biology, biomedicine, and evolution. The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models (nucleotide or amino acid), inferring ancestral states and sequences (along with probabilities), and estimating evolutionary rates site-by-site. In computer simulation analyses, ML tree inference algorithms in MEGA5 compared favorably with other software packages in terms of computational efficiency and the accuracy of the estimates of phylogenetic trees, substitution parameters, and rate variation among sites. The MEGA user interface has now been enhanced to be activity driven to make it easier for the use of both beginners and experienced scientists. This version of MEGA is intended for the Windows platform, and it has been configured for effective use on Mac OS X and Linux desktops. It is available free of charge from http://www.megasoftware.net.
Keyword:
MODEL SELECTION
LARGE PHYLOGENIES
DNA-SEQUENCES
CLOCK
NUCLEOTIDE
INFERENCE
SOFTWARE
PERFORMANCE
DIVERGENCE
ALGORITHM
期刊
IF:
5.3
论文数:
8.4K
被引数:
6.6W
机构
引用论文
分享收藏
A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood一种通过最大似然估计大型系统发育的简单，快速且准确的算法.png)
SYSTEMATIC BIOLOGYOAAI
SYSTEMATIC BIOLOGYIF5.7
OAAI分享收藏Effect of phthalate esters on serum cholesterol and lipid biosynthesis in liver, testes, and epididymal fat in the rat and rabbitLipids
LipidsIF0
PREAI
分享收藏
查看更多内容