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Mendelian Randomization Reveals Interleukin-6 Receptor-Lipoprotein(a) Interplay With Independent Cardiovascular Risk Reductions
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DOI：10.1016/j.jacbts.2026.101564.png)
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Abstract
En 中文
• IL-6R signaling and Lp(a) are causal CVD risk factors; IL-6R inhibitors lower Lp(a) but raise circulating IL-6 concentrations. • Two-sample MR supports a causal effect of IL-6R signaling on raising Lp(a). • Ignoring IL-6R functional state can confound IL-6–Lp(a) associations in epidemiological analyses. • Factorial MR shows genetically lowered IL-6R signaling and Lp(a) independently reduce CVD risk.
Keywords:
cardiovascular disease
interleukin-6 receptor
lipoprotein(a)
Mendelian randomization
CRP
C-reactive protein
CVD
cardiovascular disease
IL
interleukin
IL-6R
interleukin-6 receptor
Lp(a)
lipoprotein(a)
MR
Mendelian randomization
SNV
single-nucleotide variants
UKB
UK Biobank
Journal
IF:
7.2
Papers:
1.2K
Citations:
4.3K
Organization
No organization information available
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