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Mental health and health related quality of life in mitochondrial POLG disease
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DOI：10.1016/j.mito.2020.09.005.png)
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Abstract
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We aimed to assess the impact of POLG disease on mental health and quality of life in 15 patients using the Symptom Checklist-90-R (SCL-90-R) and Short-Form 36 Health Survey (RAND-36). We found increased scores in all nine subscales of SCL-90-R, particularly phobic anxiety, depression and somatization. Further, patients reported considerably lower scores in all RAND-36 domains. This study revealed a global decline in mental health and poor quality of life in patients with POLG disease and highlights the need for increased awareness and systematic assessment in order to improve their quality of life and mental health.
Keywords:
Epilepsy
Mental health
Mitochondrial disease
POLG
Psychological distress
Quality of life
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