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Metabolic Engineering of Escherichia coli for Efficient Production of O-Succinyl-L-Homoserine
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Longmei LiuJ
Jieyun GuX
Xiaomei LyuJ
JiaLi GuQ
Qinghai LiuY
Yu-Shu MaX
Xin-Yi Tao*M
Min Liu*D
Dong-Zhi Wei DOI：10.1016/j.bej.2026.110219.png)
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Abstract
En 中文
• Self-regulating promoters were used to dynamically regulate competing pathway. • Operon elements from flagellar system were systematically screened. • Balancing cell growth and OSH production were built via an auto-inducible system. • The highest titer ever reported for OSH in E. coli was achieved herein.
Keywords:
Self-regulating promoters
Operon elements
Auto-inducible system
O-Succinyl-L-Homoserine
Metabolic engineering
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3.8
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6.2K
Citations:
1.4W
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