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Metal-Free Visible-Lights-Induced Synthesis of Perfluoroalkyl Amide From Perfluoroalkyl Iodide
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DOI：10.1002/ajoc.70357.png)
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Abstract
En 中文
Fluoroalkyl amides have attracted significant attention in drug discovery and materials science. However, conventional synthetic methods often involve toxic reagents and multi-step procedures, limiting their practicality, safety, and sustainability. In this study, we report a visible-light-driven synthesis of perfluoroalkyl amides from amines and perfluoroalkyl iodides employing an organic photocatalyst under ambient air. This reaction proceeds under mild, metal-free conditions and demonstrates broad compatibility with various fluorinated substrates, including amines and perfluoroalkyl iodides. Moreover, when using diiodoperfluoroalkanes, compounds linking amides and other functional groups via fluoroalkylene are readily synthesized.
Keywords:
amides
fluorine
organocatalysis
photochemistry
sustainable chemistry
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