Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes

doi:10.1016/j.molmet.2025.102186

2025-06-09

Edwin De Jesus Lopez Gonzalez

Seigmund Wai Tsuen Lai

Kelani Sun

Caree R. Carson

Carlos Hernandez-Castillo

DOI：10.1016/j.molmet.2025.102186

原文链接

原文求助

摘要

En 中文

• 我们首次描述了甲基乙二醛诱导的RNA损伤的化学性质。 • 甲基乙二醛诱导的RNA损伤与2型糖尿病相关。 • 甲基乙二醛诱导的RNA损伤与糖尿病并发症相关。 • 甲基乙二醛降低RNA的稳定性及翻译。

Keyword:

Methylglyoxal

RNA damage

Diabetes

RNA stability

RNA translation

期刊

Molecular Metabolism

IF:

6.6

论文数:

2.3K

被引数:

1.2W

机构

暂无机构信息

引用论文

Methylglyoxal-Derived Nucleoside Adducts Drive Vascular Dysfunction in a RAGE-Dependent Manner

ANTIOXIDANTS

IF6.6

2024-01-10

OAAI

Lai, Seigmund Wai Tsuen; Bhattacharya, Supriyo; De Jesus Lopez Gonzalez, Edwin; Shuck, Sarah C.

Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes

METABOLISM-CLINICAL AND EXPERIMENTAL

IF11.9

2003-02-01

175

PREAI

Kilhovd, BK; Giardino, I; Torjesen, PA; Birkeland, KI; Berg, TJ; Thornalley, PJ; Brownlee, M; Hanssen, KF

Dicarbonyl proteome and genome damage in metabolic and vascular disease

BIOCHEMICAL SOCIETY TRANSACTIONS

IF4.3

2014-03-20

118

PREAI

Rabbani, Naila; Thornalley, Paul J.

Quantification of glyoxal, methylglyoxal and 3-deoxyglucosone in blood and plasma by ultra performance liquid chromatography tandem mass spectrometry: evaluation of blood specimen 通过超高效液相色谱串联质谱法定量血液和血浆中的乙二醛，甲基乙二醛和3-脱氧葡糖醛酮: 评估血液样本

CLINICAL CHEMISTRY AND LABORATORY MEDICINE

IF3.7

2014-01-01

142

PREAI

Scheijen, Jean L. J. M.; Schalkwijk, Casper G.

N6-methyladenosine-dependent regulation of messenger RNA stability 信使RNA稳定性的N6-methyladenosine-dependent调控

Nature

IF0

2013-11-27

OAAI

Xiao Wang; Zhike Lu; Adrian Gomez; Gary C. Hon; Yanan Yue; Dali Han; Ye Fu; Marc Parisien; Qing Dai; Guifang Jia; Bing Ren; Tao Pan; Chuan He

Methylglyoxal induces G:C to C:G and G:C to T:A transversions in the supF gene on a shuttle vector plasmid replicated in mammalian cells

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

IF0

2000-07-01

PREAI

Naoko Murata-Kamiya; Hiroyuki Kamiya; Hiroshi Kaji; Hiroshi Kasai

Identification of DNA adducts of methylglyoxal

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2005-08-27

106

PREAI

Frischmann, M; Bidmon, C; Angerer, J; Pischetsrieder, M

A quantitative assay for assessing the effects of DNA lesions on transcription

NATURE CHEMICAL BIOLOGY

IF13.7

2012-08-19

OAAI

You, Changjun; Dai, Xiaoxia; Yuan, Bifeng; Wang, Jin; Wang, Jianshuang; Brooks, Philip J.; Niedernhofer, Laura J.; Wang, Yinsheng

N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2016-01-11

218

OAAI

Choi, Junhong; Ieong, Ka-Weng; Demirci, Hasan; Chen, Jin; Petrov, Alexey; Prabhakar, Arjun; O'Leary, Sean E.; Dominissini, Dan; Rechavi, Gideon; Soltis, S. Michael; Ehrenberg, Mans; Puglisi, Joseph D.

Product Studies and Mechanistic Analysis of the Reaction of Methylglyoxal with Deoxyguanosine

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2018-01-31

OAAI

Shuck, Sarah C.; Wuenschell, Gerald E.; Termini, John S.

查看更多内容