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METTL3 promotes cell-cycle progression via activation of transcriptional elongation
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DOI：10.1016/j.molcel.2026.07.011.png)
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Abstract
En 中文
• CDK1 phosphorylates the m6A methyltransferase METTL3 at Ser43 upon mitotic entry • METTL3 phosphorylation allows 7SK methylation and P-TEFb release for transcription • METTL3 phosphorylation is required for timely mitotic exit and chromosome segregation • CDK1-METTL3-7SK-P-TEFb axis integrates RNA methylation into mitotic progression
Keywords:
RNA modifications
m6A
METTL3
transcription
cell cycle
DNA damage
RNA Pol II
CDK1
7SK
chromosome segregation
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