Microbial lignin Valorization through depolymerization to aromatics conversion

doi:10.1016/j.tibtech.2022.09.009

2022-12-01

PRE

谢尚县 (Shangxian Xie) *

DOI：10.1016/j.tibtech.2022.09.009

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摘要

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Lignin is the most abundant source of renewable aromatic biopolymers and its valorization presents significant value for biorefinery sustainability, which promotes the utilization of renewable resources. However, it is challenging to fully convert the structurally complex, heterogeneous, and recalcitrant lignin into high-value products. The in-depth research on the lignin degradation mechanism, microbial metabolic pathways, and rational design of new systems using synthetic biology have significantly accelerated the development of lignin valorization. This review summarizes the key enzymes involved in lignin depolymerization, the mechanisms of microbial lignin conversion, and the lignin valorization application with integrated systems and synthetic biology. Current challenges and future strategies to further study lignin biodegradation and the trends of lignin valorization are also discussed.

Keyword:

O-DEMETHYLASE

BIOCATALYTIC VALORIZATION

HETEROLOGOUS EXPRESSION

CATABOLIC PATHWAYS

CYTOCHROMES P450

ALCOHOL OXIDASE

DEGRADATION

STRAIN

GENES

VANILLATE

期刊

Trends in Biotechnology

IF:

14.9

论文数:

3.8K

被引数:

2.0W

机构

Texas A&M University System

学者数:

4.4W

论文数: 4.0W

被引数: 4.0K

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