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Microbiotherapy: an emerging adjunct for burn wound healing
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DOI：10.3389/fcimb.2026.1873498.png)
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Abstract
En 中文
Burn injuries rank among the most common types of severe trauma; typically causing damage to skin tissue. However; traditional management strategies; particularly those relying on broad-spectrum antibiotics; face the dual challenges of increased drug resistance and limited wound healing efficacy; necessitating urgent development of novel therapeutic strategies. In recent years; microbiotherapy has garnered significant attention as a potential adjuvant therapy in burn wound management. Microbiotherapy achieves antibacterial effects by competitively inhibiting pathogen adhesion and secreting metabolites. Additionally; it promotes burn wound healing through the secretion of anti-inflammatory and growth factors; as well as the restoration of immune homeostasis. This approach aligns with the field’s shift toward personalized therapy; where microbial interventions can be tailored to the specific microenvironment of a patient’s wound. Current microbiotherapies for burn treatment primarily focus on probiotics; bacteriophages; and microbial metabolic derivatives. These therapies can be used individually or in combination and are gradually transitioning from laboratory early-stage research to clinical application. Probiotics; the core component of microbiotherapy; exert their therapeutic effects mainly by secreting various metabolites. This review summarizes the latest advances in microbiotherapy for burn wound treatment; focusing on its mechanisms of action; in vivo studies; and potential combined applications. Furthermore; this review critically evaluates the future opportunities and translational challenges of microbiotherapy to provide a balanced perspective on its clinical viability.
Keywords:
probiotics
bacteriophage
burn
microbiotherapy
burn wound healing
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