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Microengineering of cellular interactions

delete2000-08-01
delete620
PRE
AI
A
Albert Folch
M
Mehmet Toner
DOI：10.1146/annurev.bioeng.2.1.227delete
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摘要

摘要

En 中文
Tissue function is modulated by an intricate architecture of cells and biomolecules on a micrometer scale. Until now, in vitro cellular interactions were mainly studied by random seeding over homogeneous substrates. Although this strategy has led to important discoveries, it is clearly a nonoptimal analog of the in vivo scenario. With the incorporation-and adaptation-of microfabrication technology into biology, it is now possible to design surfaces that reproduce some of the aspects of that architecture. This article reviews past research on the engineering of cell-substrate, cell-cell, and cell-medium interactions on the micrometer scale.
Keyword:
cellular patterns
micropatterning
cell-cell interactions
cellular microdevices
lithography

期刊

Annual Review of Biomedical Engineering 封面图
Annual Review of Biomedical Engineering
IF:
9.6
论文数:
482
被引数:
5.6K

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