.png){kind=icon}
返回
Microenvironment-triggered multimodal precision diagnostics
.png){kind=icon}
PRE
AI
DOI：10.1038/s41563-021-01042-y.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Therapeutic outcomes in oncology may be aided by precision diagnostics that offer early detection, localization and the opportunity to monitor response to therapy. Here, we report a multimodal nanosensor engineered to target tumours through acidosis, respond to proteases in the microenvironment to release urinary reporters and (optionally) carry positron emission tomography probes to enable localization of primary and metastatic cancers in mouse models of colorectal cancer. We present a paradigm wherein this multimodal sensor can be employed longitudinally to assess burden of disease non-invasively, including tumour progression and response to chemotherapy. Specifically, we showed that acidosis-mediated tumour insertion enhanced on-target release of matrix metalloproteinase-responsive reporters in urine. Subsequent on-demand loading of the radiotracer Cu-64 allowed pH-dependent tumour visualization, enabling enriched microenvironmental characterization when compared with the conventional metabolic tracer F-18-fluorodeoxyglucose. Through tailored target specificities, this modular platform has the capacity to be engineered as a pan-cancer test that may guide treatment decisions for numerous tumour types. Multimodal nanosensors have been developed to target and respond to hallmarks in the tumour microenvironment and provide both a non-invasive urinary monitoring tool and an on-demand positron emission tomography imaging agent to localize tumour metastasis and assess response to therapy.
Keyword:
TUMOR
CANCER
PH
ACIDOSIS
PET
CHEMOTHERAPY
METABOLISM
RESISTANCE
PEPTIDES
FAMILY
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
38.5
论文数:
6.8K
被引数:
11.5W
机构
引用论文
分享收藏Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA通过监测循环游离DNA在KRASG12D-driven小鼠肺癌模型中早期检测癌前病变
OAAI
OAAI分享收藏Detecting cancers through tumor-activatable minicircles that lead to a detectable blood biomarkerOAAI
OAAI分享收藏Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix使用靶向细胞外基质的纳米抗体对肿瘤进展，转移和纤维化进行无创成像OAAI
OAAI分享收藏Chemotherapy-generated cell debris stimulates colon carcinoma tumor growth via osteopontin.png)
FASEB JOURNALOAAI
FASEB JOURNALIF4.2
OAAI分享收藏Microenvironmental regulation of tumor progression and metastasis肿瘤进展和转移的微环境调控NATURE MEDICINE
OAAI
NATURE MEDICINEIF50
OAAI分享收藏Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA使用无细胞DNA中的甲基化特征进行敏感和特异性的多癌症检测和定位ANNALS OF ONCOLOGYOAAI
ANNALS OF ONCOLOGYIF65.4
OAAI分享收藏
查看更多内容