.png){kind=icon}
返回
Microfluidic scaffolds for tissue engineering
.png){kind=icon}
PRE
AI
DOI：10.1038/nmat2022.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Most methods to culture cells in three dimensions depend on a cell-seedable biomaterial to define the global structure of the culture and the microenvironment of the cells. Efforts to tailor these scaffolds have focused on the chemical and mechanical properties of the biomaterial itself. Here, we present a strategy to control the distributions of soluble chemicals within the scaffold with convective mass transfer via microfluidic networks embedded directly within the cell-seeded biomaterial. Our presentation of this strategy includes: a lithographic technique to build functional microfluidic structures within a calcium alginate hydrogel seeded with cells; characterization of this process with respect to microstructural fidelity and cell viability; characterization of convective and diffusive mass transfer of small and large solutes within this microfluidic scaffold; and demonstration of temporal and spatial control of the distribution of non-reactive solutes and reactive solutes (that is, metabolites) within the bulk of the scaffold. This approach to control the chemical environment on a micrometre scale within a macroscopic scaffold could aid in engineering complex tissues.
Keyword:
ALGINATE HYDROGELS
CHONDROCYTES
FABRICATION
CARTILAGE
CELLS
BIOREACTORS
CONSTRUCTS
PHENOTYPE
GRADIENTS
DENSITY
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
38.5
论文数:
6.8K
被引数:
11.5W
机构
暂无机构信息
引用论文
Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element.png)
LAB ON A CHIP
LAB ON A CHIPIF5.4
PREAI
分享收藏Graph theory analysis of cortical thickness networks in adolescents with d‐transposition of the great arteries大动脉d ‐ 转位青少年皮层厚度网络的图论分析
OAAI
OAAI分享收藏
查看更多内容