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Microfluidics for understanding model organisms
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DOI：10.1038/s41467-022-30814-6.png)
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摘要
En 中文
New microfluidic systems for whole organism analysis and experimentation are catalyzing biological breakthroughs across many fields, from human health to fundamental biology principles. This perspective discusses recent microfluidic tools to study intact model organisms to demonstrate the tremendous potential for these integrated approaches now and into the future. We describe these microsystems' technical features and highlight the unique advantages for precise manipulation in areas including immobilization, automated alignment, sorting, sensory, mechanical and chemical stimulation, and genetic and thermal perturbation. Our aim is to familiarize technologically focused researchers with microfluidics applications in biology research, while providing biologists an entree to advanced microengineering techniques for model organisms. Building small-scale tools for biology research eliminates the need for time-consuming methods and enables novel experimental paradigms. Here, the authors discuss microfluidics' potential for manipulating or stimulating model organisms and identify barriers to making these tools accessible.
Keyword:
CAENORHABDITIS-ELEGANS
DROSOPHILA EMBRYO
C. ELEGANS
IN-VIVO
MECHANOSENSORY TRANSDUCTION
MECHANICAL STIMULATION
BEHAVIORAL-ANALYSIS
LATERAL-LINE
SYSTEM
TEMPERATURE
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期刊
IF:
15.7
论文数:
9.3W
被引数:
91.2W
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分享收藏Microfluidic chamber arrays for whole-organism behavior-based chemical screening.png)
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