.png){kind=icon}
返回
Microphysiological systems for human aging research
.png){kind=icon}
OA
AI
DOI：10.1111/acel.14070.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Recent advances in microphysiological systems (MPS), also known as organs-on-a-chip (OoC), enable the recapitulation of more complex organ and tissue functions on a smaller scale in vitro. MPS therefore provide the potential to better understand human diseases and physiology. To date, numerous MPS platforms have been developed for various tissues and organs, including the heart, liver, kidney, blood vessels, muscle, and adipose tissue. However, only a few studies have explored using MPS platforms to unravel the effects of aging on human physiology and the pathogenesis of age-related diseases. Age is one of the risk factors for many diseases, and enormous interest has been devoted to aging research. As such, a human MPS aging model could provide a more predictive tool to understand the molecular and cellular mechanisms underlying human aging and age-related diseases. These models can also be used to evaluate preclinical drugs for age-related diseases and translate them into clinical settings. Here, we provide a review on the application of MPS in aging research. First, we offer an overview of the molecular, cellular, and physiological changes with age in several tissues or organs. Next, we discuss previous aging models and the current state of MPS for studying human aging and age-related conditions. Lastly, we address the limitations of current MPS and present future directions on the potential of MPS platforms for human aging research. Age is one of the risk factors for many diseases, and enormous interest has been devoted to aging research. A human aging model using microphysiological systems (MPS) can provide a predictive tool to understand the molecular and cellular mechanisms underlying the human aging process and age-related diseases. Here, we provide a review on the application of MPS in aging research.image
Keyword:
age-related changes
age-related diseases
aging
aging phenotypes
microphysiological systems
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
7.1
论文数:
3.7K
被引数:
1.9W
机构
引用论文
Anaerobic Digestion and Alternative Manure Management Technologies for Methane Emissions Mitigation on Californian Dairies.png)
Atmosphere
OAAI
AtmosphereIF0
OAAI分享收藏Online oxygen monitoring using integrated inkjet-printed sensors in a liver-on-a-chip systemLAB ON A CHIPOAAI
LAB ON A CHIPIF5.4
OAAI分享收藏Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine结直肠肿瘤芯片系统: 用于精确肿瘤纳米医学的3D工具SCIENCE ADVANCESOAAI
SCIENCE ADVANCESIF12.5
OAAI分享收藏
查看更多内容