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Microplastics induce osteoporosis via dose‐divergent mechanisms: Multi‐omics reveal metabolic compensation and inflammatory senescence

delete2026-07-24
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OA
AI
J
Jiawei Zhang
Y
Yafen Wang
Y
Yongfeng Zhang
P
Peng Zhang
G
Guangwei Zhang
D
Dongsheng Pan
Z
Zhuowen Liang
C
Chaoqun Jin
B
Beiyu Chen
王哲 cover
王哲 (Zhe Wang)
Z
Zipeng Cao *
P
Peng Liu *
T
Tan Ding *
DOI：10.1016/j.hazadv.2026.101426delete
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Abstract

Abstract

En 中文
• First identified dose-divergent effects of microplastics in osteoporosis via distinct bone metabolic pathways. • Integrated metabolomics and DIA-proteomics to reveal molecular networks in microplastic-induced bone injury. • Identified Pg 34:1 and quinic acid as early biomarkers for microplastic-induced osteoporosis.
Keywords:
Microplastics
Osteoporosis
Bone metabolism
Metabolic biomarker (Pg 34:1, Quinic Acid)
Multi‐omics

Journal

Journal of Hazardous Materials Advances cover
Journal of Hazardous Materials Advances
IF:
7.7
Papers:
1.4K
Citations:
3.1K

Organization

N
Northwest A&F University
Scholars:
9.5K
Papers: 2.5K
Citations: 4.2W
T
the fourth military medical university
Scholars:
1.4K
Papers: 259
Citations: 0
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