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Microsatellites: Simple sequences with complex evolution
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DOI：10.1038/nrg1348.png)
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摘要
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Few genetic markers, if any, have found such widespread use as microsatellites, or simple/short tandem repeats. Features such as hypervariability and ubiquitous occurrence explain their usefulness, but these features also pose several questions. For example, why are microsatellites so abundant, why are they so polymorphic and by what mechanism do they mutate? Most importantly, what governs the intricate balance between the frequent genesis and expansion of simple repetitive arrays, and the fact that microsatellite repeats rarely reach appreciable lengths? In other words, how do microsatellites evolve?
Keyword:
STEPWISE MUTATION MODEL
MISMATCH REPAIR PROFICIENT
SIMPLE REPETITIVE DNA
HUMAN Y-CHROMOSOME
SACCHAROMYCES-CEREVISIAE
DROSOPHILA-MELANOGASTER
DINUCLEOTIDE REPEAT
DELETION MUTATIONS
ESCHERICHIA-COLI
RELATIVE RATES
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52
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4.0K
被引数:
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引用论文
Mutational analyses of dinucleotide and tetranucleotide microsatellites in Escherichia coli:: Influence of sequence on expansion mutagenesis.png)
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