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Microscale Interfacial Polymerization on a Chip
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DOI：10.1002/anie.202110974.png)
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摘要
En 中文
Forming hydrogels with precise geometries is challenging and mostly done using photopolymerization, which involves toxic chemicals, rinsing steps, solvents, and bulky optical equipment. Here, we introduce a new method for in situ formation of hydrogels with a well-defined geometry in a sealed microfluidic chip by interfacial polymerization. The geometry of the hydrogel is programmed by microfluidic design using capillary pinning structures and bringing into contact solutions containing hydrogel precursors from vicinal channels. The characteristics of the hydrogel (mesh size, molecular weight cut-off) can be readily adjusted. This method is compatible with capillary-driven microfluidics, fast, uses small volumes of reagents and samples, and does not require specific laboratory equipment. Our approach creates opportunities for filtration, hydrogel functionalization, and hydrogel-based assays, as exemplified by a rapid, compact competitive immunoassay that does not require a rinsing step.
Keyword:
capillary-driven flow
hydrogels
interfaces
microfluidics
polymerization
期刊
IF:
16.9
论文数:
5.7W
被引数:
53.0W
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引用论文
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BIOMATERIALS
OAAI
BIOMATERIALSIF12.9
OAAI分享收藏Single-step design of hydrogel-based microfluidic assays for rapid diagnosticsLAB ON A CHIP
LAB ON A CHIPIF5.4
PREAI
分享收藏Visualization and characterization of interfacial polymerization layer formationLAB ON A CHIPOAAI
LAB ON A CHIPIF5.4
OAAI分享收藏
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