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Microstructured liposome array
DOI:10.1021/bc050273p.png)
摘要
En 中文
Conversion of a DNA chip to a nanocapsule array was performed by grafting on a liposome an oligonucleotide complementary to an oligonucleotide bound to the array. Each liposome may be loaded by a soluble molecule or may present a hydrophobic or amphiphilic molecule inserted in its wall. To detect liposomes on the chip, we used fluorescent dyes encapsulated in the liposome internal volume or fluorescent lipids. We observed that an oligonucleotide-grafted liposome containing a defined dye specifically accumulated on the area where its complementary oligonucleotide had been spotted on the array. The virtually unlimited amount of addresses allows the specific binding of large amounts of liposomes in one single batch.
Keyword:
PROTEIN MICROARRAYS
DNA MICROARRAYS
GLASS SLIDES
ACETYLCHOLINESTERASE
ENCAPSULATION
BILAYERS
期刊
IF:
3.9
论文数:
7.2K
被引数:
1.6W
机构
暂无机构信息
引用论文
Dendrimeric coating of glass slides for sensitive DNA microarrays analysis -: art. no. e88
NUCLEIC ACIDS RESEARCH
IF13.1
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