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Microtesla MRI with a superconducting quantum interference device
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DOI：10.1073/pnas.0402382101.png)
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摘要
En 中文
MRI scanners enable fast, noninvasive, and high-resolution imaging of organs and soft tissue. The images are reconstructed from NMR signals generated by nuclear spins that precess in a static magnetic field B-0 in the presence of magnetic field gradients. Most clinical MRI scanners operate at a magnetic field B-0 = 1.5 T, corresponding to a proton resonance frequency of 64 MHz. Because these systems rely on large superconducting magnets, they are costly and demanding of infrastructure. On the other hand, low-field imagers have the potential to be less expensive, less confining, and more mobile. The major obstacle is the intrinsically low sensitivity of the low-field NMR experiment. Here, we show that prepolarization of the nuclear spins and detection with a superconducting quantum interference device (SQUID) yield a signal that is independent of B-0, allowing acquisition of high-resolution MRIs in microtesla fields. Reduction of the strength of the measurement field eliminates inhomogeneous broadening of the NMR lines, resulting in enhanced signal-to-noise ratio and spatial resolution for a fixed strength of the magnetic field gradients used to encode the image. We present high-resolution images of phantoms and other samples and T-1-weighted contrast images acquired in highly inhomogeneous magnetic fields of 132 muT; here, T, is the spin-lattice relaxation time. These techniques could readily be adapted to existing multichannel SQUID systems used for magnetic source imaging of brain signals. Further potential applications include low-cost systems for tumor screening and imaging peripheral regions of the body.
Keyword:
NUCLEAR-MAGNETIC-RESONANCE
FIELD
NMR
RELAXATION
SYSTEM
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9.1
论文数:
10.8W
被引数:
73.5W
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