Microvolume field-effect pH sensor for the scanning probe microscope

Manalis, SR

doi:10.1063/1.125942

2000-02-21

PRE

DOI：10.1063/1.125942

原文求助

摘要

En 中文

A pH sensitive scanning probe is realized by integrating a micron-sized field-effect sensor onto a cantilever designed for an atomic force microscope. The hybrid device, called a scanning probe potentiometer (SPP), is capable of measuring pH gradients over a sample surface. The device was used to profile the pH across a reservoir of laminar streams created by fluid flow in an array of microfluidic channels of varying pH. When a single SPP scanned, a 1.5 mm reservoir in a 10-channel array, the pH profile was measured in less than 1 min with a spatial resolution of 10 mu m and sensitivity of less than 0.01 pH units. (C) 2000 American Institute of Physics. [S0003-6951(00)01307-3].

Keyword:

ADDRESSABLE POTENTIOMETRIC SENSOR

ATOMIC-FORCE MICROSCOPE

BIOLOGICAL APPLICATIONS

IMAGING SENSOR

DNA

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期刊

Applied Physics Letters

IF:

3.6

论文数:

10.4W

被引数:

17.8W

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暂无机构信息

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