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Midlife insulin resistance and brain beta-amyloid accumulation as predictors of change in late-life cognitive function – a 20-year follow-up study
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DOI：10.1016/j.neurobiolaging.2026.06.004.png)
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Abstract
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• Midlife insulin resistance increased risk of episodic memory decline in late-life • Late-life brain beta-amyloid burden predicted a greater decline in episodic memory • Aβaccumulation mediates the effect of midlife IR on late-life episodic memory • Our results suggest a link between insulin resistance and Alzheimer´s disease
Keywords:
insulin resistance
brain beta-amyloid
positron emission tomography
cognition
episodic memory
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