Minimized proteins

doi:10.1016/S0959-440X(97)80107-8

1997-08-01

101

PRE

Brian C. Cunningham *

James A. Wells

DOI：10.1016/S0959-440X(97)80107-8

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摘要

En 中文

The design of bioactive small molecules for interaction at larger protein-protein interfaces remains a challenge. Recent progress towards minimizing proteins into significantly smaller polypeptides has been achieved via both rational design processes and selection from vast combinatorial libraries. Such 'mini-proteins' represent a potential intermediate step toward the development of drugs targeted to protein-protein interfaces.

Keyword:

PEPTIDE

PHAGE

RECEPTOR

NONPEPTIDE

LIBRARIES

LIGANDS

HORMONE

VARIANT

DESIGN

POTENT

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期刊

Current Opinion in Structural Biology

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3.8K

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