Mitochondria in multiple sclerosis

Ghafourifar, Pedram

doi:10.2741/2913

Mitochondria in multiple sclerosis

2008-01-01

52

OA

AI

G

Ghafourifar, Pedram *

DOI：10.2741/2913

查看原文

摘要

En 中文

Multiple sclerosis (MS) is a neurological disorder of the central nervous system characterized by demyelination and neurodegeneration. Although the pathogenesis of MS is not completely understood, various studies suggest that immune-mediated loss of myelin and mitochondrial dysfunction are associated with the disease. Mitochondria are one of the main cellular sources of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and play a pivotal role in many neuropathological conditions. Mitochondrial dysfunction leading to excessive production of ROS and RNS plays a significant role in the pathogenesis of MS, particularly in loss of myelin/oligodendrocyte complex. The present review summarizes critical role of mitochondria in the pathogenesis of MS. Further understanding of the role of mitochondria in MS may provide rationale for novel approaches to this disease and development of novel therapeutic maneuvers.

Keyword:

mitochondria

multiple sclerosis

oxidative

nitrative stress

experimental autoimmune encephalomyelitis

reactive oxygen species

reactive nitrogen species

peroxynitrite

apoptosis

review

Mitochondria in multiple sclerosis

摘要

AI总结

期刊

机构

引用论文