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Mitochondrial DNA analysis in a cohort of stillbirths with brainstem and cardiac conduction system abnormalities

delete2026-04-02
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M
Mauro Lecca
N
Nicolò Mele
P
Patrizia Leonardi
G
Giulia Ottaviani
E
Edoardo Errichiello *
DOI:10.1016/j.mito.2026.102152delete
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Abstract

Abstract

En 中文
• Mt-DNA was analysed in the affected brainstem tissues from 42 stillbirths. • A higher mtDNA copy number was observed in cases compared with controls. • D-loop methylation levels were higher in affected brainstem tissues compared with controls. • Mitochondrial dysfunction is a key contributor to fetal demise, and mtDNA-CN is a potential biomarker for SB.
Keywords:
Stillbirth (SB)
Brainstem
cardiac conduction system (CCS)
mitochondrial DNA (mtDNA)
mitochondrial DNA copy number (mtDNA-CN)
displacement loop (D-loop)
Methylation
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MITOCHONDRION cover
MITOCHONDRION
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4.5
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Citations:
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U
university of milan
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U
university of pavia
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