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Mitochondrial iron overload is associated with lysosomal dysfunction-mediated mitophagy impairment in the heart of Friedreich’s ataxia
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DOI：10.1016/j.mito.2026.102120.png)
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Abstract
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• Mitochondrial iron deposits are associated with altered mitochondrial ultrastructure (cristae) and impaired mitochondrial function under cardiac frataxin deficiency, which may lead to Friedreich’s ataxia-related cardiomyopathy. • Dysfunctional lysosomal capacity may contribute to impaired clearance of dysfunctional mitochondria in the context of cardiac-specific frataxin deficiency.
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