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Mitochondrial responses to thermal stress: ROS dynamics and metabolic shifts in Drosophila
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DOI：10.1016/j.mito.2026.102114.png)
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Abstract
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• Mitochondrial H2O2 emission in Drosophila shows distinct site-associated and energetic state thermal sensitivity. • NADH-linked pathways exhibit high ROS production and functional decline at elevated temperatures. • FADH2-linked substrates support respiration at high temperature decoupled from ROS production. • An increased reliance on FADH2-linked substrate oxidation may mitigate ROS production during thermal challenge.
Keywords:
Thermal sensitivity
Reactive oxygen species
Mitochondrial oxygen consumption
Enzymatic activities
Drosophila melanogaster
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