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摘要
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All eukaryotic cells prepare for cell division by forming a mitotic spindle-a bipolar machine made from microtubules (MTs) and many associated proteins. This device organizes the already duplicated DNA so one copy of each chromosome attaches to each end of the spindle. Both formation and function of the spindle require controlled MT dynamics, as well as the actions of multiple motor enzymes. Spindle-driven motions separate the duplicated chromosomes into two distinct sets that are then moved toward opposite ends of the cell. The two cells that subsequently form by cytokinesis, therefore, contain all the genes needed to grow and divide again.
Keyword:
SPINDLE ASSEMBLY CHECKPOINT
XENOPUS EGG EXTRACTS
AURORA-A KINASE
MITOTIC SPINDLE
IN-VITRO
MICROTUBULE DYNAMICS
CHROMOSOME SEGREGATION
NUCLEAR-ENVELOPE
SACCHAROMYCES-CEREVISIAE
3-DIMENSIONAL STRUCTURE
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10.1
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被引数:
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Human chromokinesins promote chromosome congression and spindle microtubule dynamics during mitosis.png)
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收藏The polarity and dynamics of microtubule assembly in the budding yeast Saccharomyces cerevisiae.png)
NATURE CELL BIOLOGY
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NATURE CELL BIOLOGYIF19.1
OAAI分享收藏Poleward microtubule flux is a major component of spindle dynamics and anaphase A in mitotic Drosophila embryosCURRENT BIOLOGYOAAI
CURRENT BIOLOGYIF7.5
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